Migrant workers’ independent entrepreneurship is an important way to properly deal with the resettlement of rural surplus labor force under the background of “ mass entrepreneurship and innovation”. The resource endowment accumulated by migrant workers during their work is the key step to get past the threshold of initial creation. Based on data of China Labor-force Dynamic Survey ( CLDS) 2016, this paper systematically analyzes the influence of many factors, including migrant workers’ experience, on their entrepreneurial decision-making, and focuses on the moderating and demonstration effect of neighborhood relationship. Theoretical analysis and empirical results show that the experience of migrant workers significantly improves the probability of entrepreneurship of rural labor force. Compared with the entrepreneurial environment, migrant workers pay more attention to the abundance of their factor endowment when making entrepreneurial decisions. For the group with high subjective well-being, strong sense of unfairness, not taking part in short-term technical training and entrepreneurship in the western region, the variable of migrant workers ’ experience has a higher promoting effect on entrepreneurial activities. Neighborhood relationship has a positive moderating effect on migrant workers’ experience and entrepreneurial behavior. Neighborhood support effect, group effect and demonstration effect are effective channels for the moderating effect. The above conclusion is still valid after the robustness and endogenous test, which provides a useful reference for stimulating the endogenous power of rural entrepreneurship and realizing the revitalization of rural industry and talents as soon as possible.